IAPP and Cachexia: This, in turn, leads to an acid-mediated tumour invasion and the impairment of mitochondrial functions in cancer cells, (ii) the production of tumour-specific factors such as islet amyloid polypeptide (IAPP), which contributes to cachexia and the loss of appetite, and (iii) the location of the tumour itself, most often in the head of the pancreas, resulting in the reduction of the secretion of pancreatic enzymes during meals [6].