In contrast, HSP treated mice presented an ameliorated anti-inflammatory reaction resulting in significantly decreased levels of IL-33 and TNF-α in mice that were cotreated with HSP and LPS; however, no significant effect was observed in the IL-33 and TNF-α levels in the mice injected with only HSP when compared to the control and cotreated mice. Here, TNF is linked to hereditary spastic paraplegia.