In addition, C57BL/6J Tg expressing human MHC alleles such as HLA, A*0201, A*0101, A*1101, B*0701, and DRB1*0101 have been developed to study T cells in the context of viral infections [87,88,89] opening the possibility of using C57BL/6J-MHC Tg or IFNα/βR−/−-MHC Tg to identify T-cell epitopes relevant to protection against dengue. This evidence concerns the gene HLA-C and dengue disease.