For example, cytokines IL-4 and IL-10 secreted by tumor cells or T cells can polarize macrophages to their M2 state in which they are capable of secreting TGF-B1 and CXCL12 to inhibit CD8+ T cell function in support of tumor cell survival and metastasis [26,27,28]. This evidence concerns the gene TGFB1 and neoplasm.