In the small intestine, taste receptors on DCLK1+ tuft cells detect threats and secrete IL-25, which binds its receptors (IL-17Rb) on type 2 innate lymphoid cells (ILC2s), inducing IL-4/13 secretion, which activates IL-4 receptors and induces tuft and goblet cell hyperplasia, which can initiate tumors and support progression and metastasis when harboring mutations [14,46,47,48,55], but few studies have assessed DCLK1′s role in tumor immunity. The gene discussed is IL4; the disease is neoplasm.