TIGIT and colon adenocarcinoma: Specifically, higher DCLK1 expression is associated with increased Treg (FOXP3, CCR8, STAT5B, TGF-B1, CD25, and CD4) and T cell exhaustion markers (PD-1, CTLA4, LAG3, TIM-3, TIGIT, and BTLA) in COAD and STAD (Table 1).