The expression level of proteins involved in extracellular matrix remodeling, such as MMP1, MMP3, TNC as well as KGF and stroma cell-derived factor 1 alpha, has been associated with the NBCCS-BCCs aggressive clinical phenotype since patients presenting a high number of large BCCs show a higher level of expression compared to non-aggressive clinical phenotype [102]. Here, MMP3 is linked to nevoid basal cell carcinoma syndrome.