Beyond suppressing hyperglycemia, disruption of GCGR also leads to increased insulin sensitivity, hypoglycemia, hyperglucagonemia, hyperaminoacidemia, increased plasma LDL, increased GLP-1 and FGF21 levels, decreased adiposity, and hyperplasia of pancreatic α-cells in mouse models [6,14,15,16]. This evidence concerns the gene GCG and Hypoglycemia.