Obesity-induced retinal inflammation occurs particularly via nucleotide-binding oligomerization domain (NOD)-like receptor pyrin domain-containing protein 3 (NLRP3) inflammasome signaling, resulting in the activation of downstream effectors including caspase-1 and interleukin-1β (IL-1β), which are associated with ROS elevation. Here, NLRP3 is linked to obesity due to melanocortin 4 receptor deficiency.