Another apoptosis-related gene that DUX4 upregulates is MYC. Shadle et al. (2017) generated a rhabdomyosarcoma cell line stably transduced with doxycycline-inducible DUX4 (RD-DUX4i), which they proceeded to transfect with a siRNA library to search for genes that enable DUX4-mediated toxicity [54]. Here, DUX4 is linked to rhabdomyosarcoma.