Many other potential biomarkers to detect periodontitis and related systemic diseases have been investigated as well [35,36,37,38,39,40,41,42,43]; these include, along with others, asymmetric dimethylarginine (ADMA), C-reactive protein, interferon gamma (IFN-γ), interleukin-6 (IL-6), macrophage inflammatory protein-1α (MIP-1α), PMN elastase, vitamin C and also antioxidants [35,36,37,38,39,40,41,42,43]. This evidence concerns the gene IL6 and periodontitis.