A combination of clofarabine (640 nM and 50 nM in MCF7 and MDA-MB-231 cells, respectively) and EGCG (10 μM) also induced apoptosis in human breast cancer cells, followed by hypomethylation of the tumor suppressor gene RARβ (retinoic acid receptor β) and the upregulation of RARβ, PTEN, and CDKN1A genes [52]. This evidence concerns the gene RARB and breast carcinoma.