In colon cancer cells (Caco2, HCT116, HT29, SW480, and SW837 lines) and SW837 mouse xenograft, EGCG impacted on VEGF/VEGFR axis suppressing VEGFR2 (a primary responder to VEGF signal), together with HIF-1α, ERK, and AKT [137]. The gene discussed is AKT1; the disease is colonic neoplasm.