For example, in human gastric cancer SGC7901 cells (in hypoxic state) EGCG (5, 10, 20, 40 μM), reduced expressions of HIF-1α (a subunit of a heterodimeric transcription factor hypoxia-inducible factor 1-HIF1) and VEGF with a concentration-dependent effect. Here, HIF1A is linked to gastric cancer.