In a human colon cancer cell line (HT-29), it was found that EGCG activated phospho-AKT, phospho-ERK, phospho-JNK, and phospho-p38α/γ/δ and, consequently, induced cell death, a potential mechanism for anti-cancer effect of EGCG [108]. This evidence concerns the gene AKT1 and malignant colon neoplasm.