HIF1A and gastric cancer: Similarly, in gastric cancer 5-fluorouracil (5-FU) resistant cells (MGC803/FU treated with 100 μg/mL and SGC7901/FU treated with 20 μM), EGCG inhibited VEGF and HIF-1 expression, reversing 5-FU resistance that is mediated by VEGF pathway [133,134].