Moreover, in B-cell chronic lymphocytic leukemia (B-CLL), EGCG 3–25 μM reduced VEGF-R1 and VEGF-R2 phosphorylation (fundamental in B-CLL survival and growth) and induced apoptosis by caspase-3 activation, poly-adenosine diphosphate ribose polymerase (PARP) cleavage, and B-cell leukemia/lymphoma-2 protein (Bcl-2) [144,145]. This evidence concerns the gene CASP3 and B-cell chronic lymphocytic leukemia.