HMGA1 and cancer: One of the first lines of evidence indicating that HMGA mRNAs participate in the ceRNA network came from the identification and characterization of two HMGA1 non-coding processed pseudogenes, HMGA1P6 and HMGA1P7. The conserved seed sequences in miRNAs that target the HMGA1 and HMGA2 mRNAs that are also present in the HMGA1 pseudogenes transcripts can protect HMGA mRNAs from miRNA inhibition; therefore, pseudogene overexpression can sustain cancer cell proliferation and migration and inhibit cell death [269].