Validated, relevant miR-33b targets include PIM1 [253] and XIAP, both of which are involved in apoptosis [254], and ZEB1 [102,255], and the aforementioned TWIST1 [102], whose cooperation in the miR-33b/HMGA2/Twist1/ZEB1 axis plays an important role in modulating melanoma dissemination [102]. This evidence concerns the gene ZEB1 and melanoma.