In addition to HMGA2 truncation, a decrease in let-7 expression can be solely responsible for the increased expression of otherwise normal HMGA2 or HMGA1 [51] in several different cancers, such as breast [69], gastric [70] and non-small cell lung cancers [63], sarcomas [197,198], hepatocellular carcinomas, nasopharyngeal [72] and oesophageal squamous cell carcinomas [199], uterine leiomyomas and leiomyosarcomas [66,200], and pituitary adenomas [201], as a loss of let-7 expression is a marker for less well-differentiated cancers [46]. The gene discussed is HMGA2; the disease is hepatocellular carcinoma.