Recently, a new layer of miR-16/HMGA2 regulation in pituitary tumours has been added—ribosomal protein SA pseudogene 52 (RPSAP52), an antisense lncRNA targeting the HMGA2 gene was demonstrated to increase HMGA2 protein expression via a ceRNA mechanism, in which it acts as a sponge for miR-16 and miR-15 [48]. Here, HMGA2 is linked to pituitary tumor.