HMGA1 and pituitary gland adenoma: Interestingly, both works showed an inverse association between miR-16 and HMGA expression levels in human pituitary adenomas; in fact, they found that miR-16 was downregulated, but HMGA1 and HMGA2 were upregulated in pituitary adenomas when compared to normal pituitary tissues, consistent with the action of miR-16 in regulating the expression of HMGA1 and HMGA2 [50,83].