MYC and plasma cell myeloma: In this context, the administration of let-7g miRNA was shown to sensitize fluorouracil-resistant human hepatoma cells [292], whereas a locked nucleic acid-GapmeR (LNA-GapmeR) containing a let-7b mimic was shown to suppress tumour growth in vivo by regulating MYC expression in multiple myeloma and potentially in other MYC-dependent cancers [293].