HMGA2 and cancer: We (i) provide insights into the structural organization of HMGA genes; (ii) offer a complete overview of HMGA-targeting miRNAs, focusing on those that have been more deeply investigated; (iii) discuss the hypothesis of the mutual influence of HMGA1/HMGA2; and, (iv) highlight the role of HMGA mRNAs as competing endogenous RNA (ceRNA) molecules in the context of cancer initiation and development.