In breast cancer aptamers are gaining momentum, and they find usage in therapy, as well as in the detection of diagnostic and prognostic markers such as aberrant HER-2 forms [112,113], α-estrogen receptor status [114], vascular endothelial growth factor (VEGF) [115], osteopontin [116], Michigan Cancer Foundation-7 (MCF-7) cells [117], anterior gradient homolog 2 (AGR-2) protein [118]. This evidence concerns the gene AGR2 and breast cancer.