Indeed, immune microenvironment, antigen stimuli and antigen-presenting cells, such as dendritic cells appear to be connected in a complex network involving WNT/CTNNB1 pathway, a well-known driver of cancer aggressiveness and tumor-dissemination with fundamental implication for immune landscape, therapeutic approaches and patient molecular stratification in a plethora of solid tumors [78,79]. The gene discussed is CTNNB1; the disease is neoplasm.