Our previous research has demonstrated that cyclin G2 has a role in inhibiting glomerulosclerosis in DN,17 but increasing evidence showed that the degree of renal function injury is more closely related to tubulointerstitial fibrosis.22 In this study, we found low expression of cyclin G2 in the kidneys of STZ‐induced diabetic mice and high glucose–induced HK‐2 cells (Figure 1), suggesting that cyclin G2 could be involved in modulating tubulointerstitial fibrosis in DN; the mechanism by which this may occur requires further exploration. The gene discussed is CCNG2; the disease is liver dysplastic nodule.