Metabolic factors and activation of some signalling pathways are thought to be the driving force behind renal cell injury and DN.49, 50 Cyclin G2 is an unconventional cyclin that can function as a positive regulator of adipocyte differentiation through the transcriptional activity of PPARγ.51 Recently, we reported that cyclin G2 expression plays an important role in controlling glioma progression by regulating proliferation and the Warburg effect,9 which play pivotal roles in the development of DN. Here, CCNG2 is linked to central nervous system cancer.