CCNG2 and glomerulosclerosis: Previously, we reported that cyclin G2 attenuated glomerulosclerosis in DN through the Wnt pathway.17 However, it has recently been demonstrated that the development of tubulointerstitial lesions is more closely correlated with a progressive decline in renal function, compared with glomerular lesions,16, 18, 19, 20, 21, 22 and the function of cyclin G2 in tubulointerstitial fibrosis is not fully identified.