Previously, we reported that cyclin G2 attenuated glomerulosclerosis in DN through the Wnt pathway.17 However, it has recently been demonstrated that the development of tubulointerstitial lesions is more closely correlated with a progressive decline in renal function, compared with glomerular lesions,16, 18, 19, 20, 21, 22 and the function of cyclin G2 in tubulointerstitial fibrosis is not fully identified. This evidence concerns the gene CCNG2 and liver dysplastic nodule.