Moreover, a significant positive correlation between MTDH and SND1 was found in the eight GEO datasets and the TCGA-KIRC dataset, and the interaction between MTDH and SND1 at the protein level was confirmed using immunoprecipitation and immunofluorescence, which suggested that their functions and molecular mechanisms involved in tumor progression are closely connected. The gene discussed is MTDH; the disease is neoplasm.