The crosstalk between CB1 and muscarinic receptors in AD has been recently investigated using the triple transgenic mouse model of AD – the 3xTg-AD model – in which mice are homozygous for the PSEN1 (presenilin-1) mutation, APP (amyloid precursor protein) Swe transgene, and tauP301L transgene. Here, PSEN1 is linked to Alzheimer disease.