The APP/PS1 mouse model is a double transgenic mouse model, expressing a chimeric mouse/human amyloid precursor protein, and a mutant human presenilin 1(PS1-dE9), and represents a model of familial AD with cognitive impairments, Aβ plaque deposition and synaptic abnormalities from 6 months of age [138]. The gene discussed is PSEN1; the disease is Cognitive impairment.