PTEN and breast cancer: BC is a major lethal cancer in female.30 Several studies have reported that presence of genetic factors as mutations and polymorphisms (BRCA1/2, TP53, PTEN and MIF) plays an important role in the development of BC, as well as proinflammatory cytokines, like MIF.25, 31 The human MIF gene is characterized by the presence of a single nucleotide polymorphism (‐173 G > C) and a microsatellite repeat (‐794 CATT) both in the promoter region.11 The involvement of MIF alleles in the development of cancer was first associated and described in prostate cancer.19