BC is a major lethal cancer in female.30 Several studies have reported that presence of genetic factors as mutations and polymorphisms (BRCA1/2, TP53, PTEN and MIF) plays an important role in the development of BC, as well as proinflammatory cytokines, like MIF.25, 31 The human MIF gene is characterized by the presence of a single nucleotide polymorphism (‐173 G > C) and a microsatellite repeat (‐794 CATT) both in the promoter region.11 The involvement of MIF alleles in the development of cancer was first associated and described in prostate cancer.19 This evidence concerns the gene PTEN and cancer.