MIF and skin cancer: MIF protein is related to the development and progression of the tumor through the production of proangiogenic factors such as VEGF.14 Besides, MIF when forming the complex with CD74 and CD44 (also, interacts with CXCR2, CXCR4, and CXCR7 chemokine receptors)26 activates different signaling pathways like ERK1/2, MAPK, PI3K/AKT, and NFkB, involved in proliferation, differentiation, survival, and inflammation.17, 26 Likewise, the increased soluble levels of MIF have been associated in patients with prostatic, colon, lung, and skin cancer, as well as BC.27