The inclusion of the geographical localization was substantial for this study, considering that the genetic variants may not have the same association with disease in different populations; for example, ‐173G > C has been related to BC in Chinese population.33 Similarly, the inclusion of studies from other geographic localization that have explored whether the MIF ‐173 G > C is associated with an increased risk cancer obtained the heterogeneous results. The gene discussed is MIF; the disease is breast cancer.