Though the pathogenesis of this autoimmunity still remains largely unclear, abnormalities in the T cell compartment including expansion of antigen-experienced effector T cells, increased inflammatory cytokine production, and loss of IL-10-producing Tregs have been reported, which could contribute to dysregulation of immune responses and play a role in the autoimmune complications seen in this disease [60–67]. The gene discussed is IL10; the disease is Autoimmunity.