PMP lacks three genes from MYS (ABL1, BRAF, and HRAS), but its larger design intends to be a pan-myeloid test, covering (i) genes related to sporadic MNs, (ii) genes described to confer a germline predisposition to MN, such as ANKRD26, DDX41, and SRP72 (Fig 2, S5 Table)[73][74], and (iii) regions frequently affected by CNV, namely del (7q)/-7, del(5q), del(20q) and trisomy 8. This evidence concerns the gene DDX41 and Melnick-Needles syndrome.