This classification includes the genetic characterization of genes such as JAK2, MPL and CALR for Myeloproliferative Neoplasms (MPN); ASXL1, CEBPA, DNMT3A, FLT3, IDH1/2, KIT, KMT2A, NPM1, RUNX1, TET2, TP53 and WT1 genes for Acute Myeloid Leukemia (AML); and SF3B1, for Myelodysplastic Syndromes (MDS). This evidence concerns the gene NPM1 and acute myeloid leukemia.