Along the last few years, the scientific community has deepened its understanding on the genetic aberration associated to MN through the discovery of other recurrently mutated genes such as ASXL1, DNMT3A, EZH2, RUNX1, SRSF2, TET2, TP53 and U2AF1 in MDS [3][4], and ASXL1, CBL, EZH2, NRAS/KRAS, RUNX1, SETBP1, SRSF2 and TET2 in Chronic Myelomonocytic Leukemia (CMML) [5][6][7][8]. This evidence concerns the gene SETBP1 and chronic myelomonocytic leukemia.