PRNP and Alzheimer disease: A variety of different amyloid fibrils have been probed in vitro using p-FTAA, e.g. lysozyme, insulin and the prion protein [16], and p-FTAA has also been shown to detect both in vitro Aβ fibrils and amyloid aggregates within the brain tissue of transgenic AD mice and Drosophila [25–27].