Since D1143 enhances the beneficial effect of PD-1 neutralization in various cancers, we asked in this study whether D1143 would also enhance the anti-HIV immunity of an anti-PD-1 mAb by restoring the capacity of exhausted CD8+ cells to kill infected cells, and impact HIV loads in blood and tissues of humanized BLT mice. The gene discussed is PDCD1; the disease is cancer.