Amniotic fluid was found to induce both platelet aggregation and the release of platelet factor III as well as activate factor X and the complement factors in vitro,[13,14] leading to prolongation of coagulation times, hypofibrinogenemia, fibrinolytic activation and thrombocytopenia, and following by DIC, due to the large amount of coagulation factor and platelet depletion.[5] DIC has been reported to occur in approximately 80% of patients with amniotic fluid embolism syndrome[14] and may ultimately be the principle cause of death. Here, F10 is linked to Thrombocytopenia.