The ADRB3 Trp64Arg locus acts as a “thrifty” gene and has already been reported associating with obesity,[36] hypertension,[37] diabetes mellitus,[8] insulin resistance,[38] and glycolipid metabolism.[39] Logically, ADRB3 Trp64Arg locus may play an important role in the pathogenesis of CAD. The gene discussed is ADRB3; the disease is hypertensive disorder.