Pingyangmycin induces G2/M cell cycle arrest in cancer cell lines, and induces apoptosis,[17] down-regulates EGFR expression in tumor cells,[18] induces apoptosis of vascular endothelial cells,[19] and shares the same cytotoxic pathway with bleomycin.[17] In China, Pingyangmycin has been widely used in the treatment of keloids,[20] vascular malformations,[21] warts[22] and so on. This evidence concerns the gene EGFR and vascular malformation.