Multilobated nuclei are also uncommon.[26] Primary B-cell lymphoma of the bones is typically positive for B-cell markers: CD20, CD21, CD97a, CD45,[2] whilst immunoreactivity for CD75 and CD10 is variable.[4] Primary T-cell lymphoma of the bone is often positive for T-cell markers: CD3, CD43, CD30.[2,4] In cytogenetics and molecular studies, Huebner-Chan et al[27] showed that the majority of PLB patients have IGH gene rearrangements, but lack BCL-2/JH gene rearrangements. This evidence concerns the gene SPN and B-cell non-Hodgkin lymphoma.