EGFR and lung carcinoma: It is composed of Panax ginseng C.A., Panax notoginseng Radix, Cordyceps militaris, and Boswellia carterii BIRDWOOD and has been reported to have an anti-lung-cancer effect in xenograft animal model experiments using A549 lung cancer cells and A549/CR cells.[10,11] Therefore, in this study, we aim to assess whether or not afatinib plus HAD-B1 can improve the DCR compared with afatinib alone and to evaluate the efficacy and safety of HAD-B1 for finding the proper dose for patients with EGFR positive and locally advanced or metastatic NSCLC.