Interruption of initial insulin therapy was the primary source of right censoring (57.1% for MI; 57.7% for mortality; 57.2% for CVA; 56.6% for CHF; and 54.6% for CVD mortality) and occurred for the following 4 reasons in order of decreasing frequency: a gap of more than 180 days between 2 consecutive insulin prescriptions dispensed, discontinuation of the initial insulin therapy with no subsequent insulin refill before the study end of follow-up, switching from analogue to human insulin therapy or vice versa, or dispensing of inhaled or animal insulins. The gene discussed is INS; the disease is congestive heart failure.