INS and type 2 diabetes mellitus: Of these, 127 600 participants with type 2 diabetes initiating insulin therapy were included in the main study cohort (mean [SD] age, 59.4 [12.6] years; 68 588 men [53.8%] and 59 012 women [46.2%]), with 108 672 (85.2%) in the HI group and 18 928 (14.8%) in the AI group (Figure 1).