In particular, and in accordance with the interactions presented in this work, RAF1 targeting by miR-497 inhibits breast cancer cell growth (Li et al., 2011), whereas downregulation of miR-424 leads to aberrant cell proliferation through MEK1 (MAP2K1) upregulation in senile hemangioma (Nakashima et al., 2010). This evidence concerns the gene MAP2K1 and breast cancer.