Currently, as one of the markers of HPV‐induced transformation,23, 24 high levels of p16INK4a expression can also maintain the growth of tumor HPV‐switched cells.24 Studies show that the positive expression of p16INK4a in different cervical lesions in Chinese women is as follows: cervical cancer, CIN‐III, CIN‐II, CIN‐I, and the positive expression rates in the control group are 99.37%, 99.46%, 98.83%, 61.53%, and 19.21%. The gene discussed is CDKN2A; the disease is uterine cervix carcinoma in situ.