The p16INK4a protein is closely associated with high‐risk HPV infection in cervical precancerous lesions and cervical cancer tissues.22 High‐risk HPV infection leads to proliferation of cervical cancer cells and overexpression of p16INK4a, and overexpression of p16INK4a can be detected by immunohistochemistry. Here, CDKN2A is linked to cervical carcinoma.