However, in this study, the positive expression rates of p16INK4a gene in cervical cancer, CIN‐III, CIN‐II, CIN‐I, uterine leiomyoma, and chronic cervicitis were 100.00% (45/45) and 91.43% (32/35), 59.38% (19/32), 52.63% (20/38), 42.86% (18/42), and 26.47% (9/34), which are significantly related to the occurrence and development of cervical cancer in Mongolians (R = 0.913, P < .01), and there was a significant correlation with HPV16 infection (r = 0.753, P < .05), indicating that the p16INK4a gene shows high specificity and sensitivity. This evidence concerns the gene CDKN2A and cervical cancer.