CCND1 and breast cancer: In a previous study, Horii et al 31 have used the clustering method to examine 337 breast cancer patients from various breast cancer intrinsic subtypes with IHC staining scores for p‐AKT(Ser473), cyclin D1, P27, p‐p70S6K, p‐4EBP1 and p‐ERK1/2.