In the present study, we immunohistochemically evaluated the expression of RhoA, RhoC, ROCK-1, ROCK-2 and p53 in biopsy specimens obtained from 49 patients with stage II–III cervical squamous cell carcinoma treated with CCRT, and the relationships between the expression of these proteins and outcomes were investigated. The gene discussed is RHOA; the disease is cervical squamous cell carcinoma.