In the present study, we immunohistochemically evaluated the expression of RhoA, RhoC, ROCK-1, ROCK-2 and p53 in biopsy specimens obtained from 49 patients with stage II–III cervical squamous cell carcinoma treated with CCRT, and the relationships between the expression of these proteins and outcomes were investigated. This evidence concerns the gene RHOC and cervical squamous cell carcinoma.