The chemokine receptor CXCR4 is abundantly expressed on CLL cells.34 CXCR4 plays an important role in CLL pathobiology, as it mediates entry of CLL cells into lymph nodes, where they receive pro-survival stimuli.39 The high expression on the cell surface and the important role in CLL pathology make CXCR4 an attractive target for immunotherapy. Here, CXCR4 is linked to B-cell chronic lymphocytic leukemia.