Furthermore, CMV-responsive NKG2C+ NK cells in both CLL patients and HC show a NKp30− phenotype in CMV seropositive donors, highlighting that reduced levels of NKp30+ NK cells in the global NK cell compartment of CLL patients can arise from the NK cell subset that associates with CMV infection (Supplemental Fig. 1A, Supplemental Digital Content). Here, KLRC2 is linked to B-cell chronic lymphocytic leukemia.