To study if we can induce ADCC responses in CLL-derived NK cells towards CXCR4, a recently described Nb-Fc construct (VUN401-Fc) that targets CXCR4 was used.31,32 We pre-treated Daudi cells with VUN401, and co-cultured them with HC- or CLL-derived NK cells. Here, CXCR4 is linked to B-cell chronic lymphocytic leukemia.