However, amongst the 74 immune-associated genes downregulated by AmBisome® treatment in the liver (Figure 2), only 9.45% (7/74) returned fully to homeostatic levels (H2-M2,H2-Eb2,Cxcl1, IL6,Lag 3,Tnfsf15 andTnfrsf9 (CD137, 4–1BB), indicating a high level of residual immune activity in the liver despite the loss of discrete granulomas. The gene discussed is MAPRE2; the disease is Granuloma.