At baseline, the percentage of hypoglycemia was higher among insulin glargine plus rapid-acting insulin and insulin glargine plus DPP-4 inhibitors users than in the other treatment groups (1.3% and 1.4%, respectively, vs. 0.6% insulin glargine only and 0.7% insulin glargine plus other oral glucose-lowering drugs), but the results were not statistically different. This evidence concerns the gene INS and Hypoglycemia.