The objectives of this observational database study, conducted in real-world setting, were (i) to estimate the prevalence of patients diagnosed with T2DM treated with basal insulin (insulin glargine U100) and describe their demographic and clinical characteristics, including comorbidities, cotreatments, and metabolic control; (ii) to evaluate the pharmacoutilization of insulin glargine alone or in combination therapies with other antihyperglycemic agents in patients diagnosed with T2DM treated with basal insulin in terms of daily insulin dose, treatment pattern, and adherence to treatment. The gene discussed is INS; the disease is type 2 diabetes mellitus.