Among these 20,192 genes, a total of 416 upregulated genes (such as hedgehog acyltransferase (HHAT)) and 669 downregulated genes (such as Glycogenin 1 (GYG1), Unc-51 Like Kinase 3 (ULK3), and breakpoint cluster region protein (BCR)) were revealed between OA samples and RA samples in transcriptome data. Here, HHAT is linked to rheumatoid arthritis.