F2 and Hypofibrinogenemia: Wada et al. [11] recommend transfusion of platelets if platelet count < 50 × 109 L−1 or in those with a high risk of bleeding and a platelet count of <20 × 109 L−1, administration of Fresh Frozen Plasma (FFP) for either prolonged prothrombin time/activated partial thromboplastin time (>1.5 times normal) or decreased fibrinogen (<1.5 g dL−1) and fibrinogen concentrate or cryoprecipitate in actively bleeding patients with persisting severe hypofibrinogenemia (<1.5 g L−1) despite FFP replacement.