IGHE and Recurrent aphthous stomatitis: Almoznino et al. (12) reviewed the relationship between serum levels of IgE and demographic, clinical, and serological parameters of patients with aphthous stomatitis, and found a statistically significant relationship between the mean levels of IgE and female gender, age under 12 years, the onset and frequency of episodes of aphthous, and C-reactive protein level (CRP).