AKT1 and Alzheimer disease: By western blot analysis of the proteins related to the Tau signaling pathway in the AD rat hippocampus, it was found that KXS could upregulate the expressions of p-PI3K, p-Akt, and p-GSK-3β (S9), further inhibiting Tau hyperphosphorylation (Figures 4(a) and 4(b)).