Moreover, we also performed stratification analysis, and the results showed that the miRNA-based OS/RFS signature could be regarded as an independent prognostic factor of BC and patients in the high-risk group showed more reduced survival than patients in the low-risk group significantly after considering the various variables, such as gender, age and stages, and some molecular subtypes (ER status, HER2 status, and PR status). The gene discussed is ERBB2; the disease is breast cancer.