INS and type 2 diabetes mellitus: Numerous clinical studies have reported that metformin (1,1‐dimethylbiguanide) is a potent insulin sensitizer and has been recommended as a frontline drug in the management of T2DM.16 Besides anti‐hyperglycaemic action, metformin also exerts its pleiotropic beneficial effects via activation of the energy sensor AMP‐activated protein kinase (AMPK).