In support of this, it has been deduced that the extent of pyroptosis determines the magnitude of inflammation, and the controlled pyroptosis plays a crucial role in limiting the extent of inflammation and maintains a hemostasis state, as was observed in the early and chronic stage of apical periodontitis.15 Further, a study by Zha et al (2016) also reported that inflammasome activation was enhanced in metformin‐treated mice upon bacterial infection.19 Moreover, our observations revealed a strong and positive correlation of AMPK⍺(T172) with NLRP3 levels in the metformin group. The gene discussed is NLRP3; the disease is periapical periodontitis.