Although specific central effects cannot be ruled out as ASIC3 is expressed centrally, including in the hypothalamus (Meng, Wang, Chen, Xu, & Zhou, 2009) and trigeminal nucleus caudalis, where its expression is up‐regulated in a dural‐inflammatory mediated preclinical model of migraine (Wang et al., 2018). The gene discussed is ASIC3; the disease is migraine disorder.