In agreement with the potential efficacy of targeting ASIC signalling for migraine, it has recently been demonstrated that specific blockade of the ASIC1 subunit can inhibit NO‐evoked cutaneous allodynia in rats (Verkest et al., 2018), which supports our data and suggests that NO‐mediated attack triggering may have important central and peripheral actions on ASICs. Here, ASIC1 is linked to migraine disorder.