Several studies are in line with our results showing that the Zika virus epidemic in Brazil mostly impacted women.34, 35 The high prevalence of affected women in the SINAN‐NET databases can be explained in part by similar findings from a serological survey conducted in Micronesia.1, 3 The rate of attack of clinical cases of fever caused by Zika virus in women in Micronesia was high; however, the prevalence of positive IgM serology was higher in males, with a relative risk of 1.1 in relation to females.1, 3 This may suggest that asymptomatic infections are more frequent in males.36 This evidence concerns the gene CD40LG and infection.