Interestingly, GFAP expression was decreased during the inhibition of NF-κB in early stages while it was increased in late stages, indicating that astroglial NF-κB pathway is beneficial during early, pre-syntomatic stage of the disease and it ́s inhibition during late stage has also beneficial outcomes in SCA1 desease [121]. This evidence concerns the gene NFKB1 and spinocerebellar ataxia type 1.