BRAF and neoplasm: The benefit of determining the RAS and BRAF mutation status for the management of mCRC is well known [23] since it allows personalization of the treatment approach; similarly, the 2016 edition of the ESMO clinical practice guidelines recommend that “RAS testing should be carried out on all patients at the time of diagnosis” and that the BRAF mutation status “should be assessed alongside the assessment of tumor RAS mutational status for prognostic assessment” [3].