Coagulation disorders particularly were defined as heterozygous (1 patient in B) and homozygous G20210A mutation (0 patients), antiphospholipid syndrome (2 patients, 1 in SG and 1 in B), factor V Leiden mutation (2 patients in B), protein c/s deficiency (1 patient in B), thrombotic thrombocytopenic purpura (0 patients), or paraneoplastic coagulation disorder (1 patient in B). This evidence concerns the gene F5 and blood coagulation disease.