PLOD1 and polycystic ovary syndrome: Previous studies have shown that ADAMTS1, whose expression is LH/hCG and follicle-size dependent, and which shows rapidly induced expression (>20-fold increase in CCs after hCG treatment in humans) [42, 43], was related to follicular development and ovulation and may be involved in female infertility such as PCOS [3, 7, 8, 44, 45].