Agonist antibodies and Fc-fusion proteins that engage co-inhibitory receptors have been successful in treating murine models of autoimmunity.119 For example, cells from the draining lymph nodes of mice treated with agonistic anti-TIGIT antibodies showed reduced cell proliferation and proinflammatory cytokine production after restimulation with MOG-peptide. The gene discussed is TIGIT; the disease is Autoimmunity.