In addition to these polygenic autoimmune diseases, a recent study identified germline TIM-3 mutations in patients with subcutaneous panniculitis-like T-cell lymphoma (SPTCL).102 The mutations lead to misfolding of TIM-3 so that the protein is retained intracellularly with loss of cell surface expression. The gene discussed is HAVCR2; the disease is T-cell non-Hodgkin lymphoma.