We have previously described nanoformulations for delivery of plasmid DNA encoding IL-2 and IL-1235,36 for therapy of murine form of neuroblastoma but here we explore a new approach in human p53-deficient neuroblastoma cells based on siRNA delivery to silence ITCH ligase and so induce p73 expression to mediate apoptosis in response to DNA damaging agents or radiation. This evidence concerns the gene TP53 and neuroblastoma.