ITCH and neoplasm: In this study, we showed that ITCH and TP73 were expressed in two p53 mutant neuroblastoma cell lines, with Kelly cells expressing higher levels of both ITCH and TP73 than BE2 cells (Fig. 1), suggesting the existence of a compensating tumour suppressor pathway in the absence of functional p53 in these cell lines, and the feasibility of manipulating this pathway to induce the programmed cell death of tumour cells.