TP73 and neuroblastoma: We have previously described nanoformulations for delivery of plasmid DNA encoding IL-2 and IL-1235,36 for therapy of murine form of neuroblastoma but here we explore a new approach in human p53-deficient neuroblastoma cells based on siRNA delivery to silence ITCH ligase and so induce p73 expression to mediate apoptosis in response to DNA damaging agents or radiation.