CPNE3 and cancer: The presence of miRNA and cancer associated proteins inside cancer-derived EVs has led to the identification of several potential disease biomarkers such as CPNE3 in colorectal cancer EVs25, miR-451a in non-small cell lung cancer EVs26, and miR-451a in pancreatic ductal adenocarcinoma EVs27, all of which are associated with poor disease-free survival.