INS and obesity due to melanocortin 4 receptor deficiency: Analysis of metabolic parameters showed lower insulin (p < 0.05), HOMA-IR (p < 0.05), triglycerides levels (p < 0.05) and liver transaminases (AST, and ALT p < 0.05 for both) in PWS than controls with common obesity, suggestive of a healthier metabolic profile in the former.